Search on:
UNFOLDED PROTEIN RESPONSE
Descriptors Found:
1
Displaying:
1 .. 1
1 / 1
DeCS
Descriptor
English
:
Unfolded Protein Response
Descriptor
Spanish
:
Respuesta de Proteína Desplegada
Descriptor
Portuguese
:
Resposta a Proteínas não Dobradas
Tree Number:
G02.111.087.675.871.790.600.962
G02.111.087.693.600.850
G02.149.115.675.871.790.600.850
G02.149.115.693.600.925
G03.495.770.871.790.600.850
G05.355.315.670.600.850
Definition
English
:
A cellular response to environmental insults that cause disruptions in
PROTEIN FOLDING
and/or accumulation of defectively folded protein in the
ENDOPLASMIC RETICULUM
. It consists of a group of regulatory cascades that are triggered as a response to altered levels of
calcium
and/or the redox
state
of the
endoplasmic reticulum
. Persistent activation of the
unfolded protein response
leads to the induction of
APOPTOSIS.
See Related
English
:
Endoplasmic Reticulum Stress
Endoplasmic Reticulum-Associated Degradation
History Note
English
:
2010
Allowable Qualifiers
English
:
DE
drug effects
GE
genetics
IM
immunology
PH
physiology
RE
radiation effects
Record Number:
53752
Unique Identifier:
D056811
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS